Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B.
نویسندگان
چکیده
Amphotericin B (AmB) enhanced nitrite synthesis by murine macrophage-like J774.16 cells in a dose-dependent fashion. This effect was retained in the presence of Cryptococcus neoformans capsular polysaccharide, a known virulence factor. AmB and anticapsular antibody increased nitrite synergistically. In all cases, AmB required gamma interferon; C. neoformans cells were unable to elicit nitrite, with or without AmB.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 41 8 شماره
صفحات -
تاریخ انتشار 1997